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Findings in clinical trialshoweverare not known to reliably predict the abuse potential of drugsNonethelessevidence from single-dose studies does suggest that the recommended daily dosage of bupropion when administered in divided doses is not likely to be especially reinforcing to amphetamine or stimulant abusersHoweverhigher doses that could not be tested because of the risk of seizure might be modestly attractive to those who abuse stimulant drugs.

Do not use bupropion if you have used an MAO inhibitor in the past 14 daysA dangerous drug interaction could occurMAO inhibitors include isocarboxazidlinezolidmethylene blue injectionphenelzinerasagilineselegilinetranylcypromineand others.

You may have a higher risk of seizures if you use certain other medicines while taking bupropion.

Bedtime Steady-State Plasma Levels for Bupropion XL Compared to Bupropion SR a.

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