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In view of the lack of actual experience in the treatment of REVIA overdosepatients should be treated symptomatically in a closely supervised environmentPhysicians should contact a poison control center for the most up-to-date information.

Treatment in patients who have been able to abstain from alcohol in outpatient settings before treatment initiation.

There was limited evidence of a weak genotoxic effect of naltrexone in one gene mutation assay in a mammalian cell linein the Drosophila recessive lethal assayand in non-specific DNA repair tests with EcoliHoweverno evidence of genotoxic potential was observed in a range of other in vitro testsincluding assays for gene mutation in bacteriayeastor in a second mammalian cell linea chromosomal aberration assayand an assay for DNA damage in human cellsNaltrexone did not exhibit clastogenicity in an in vivo mouse micronucleus assay.

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naltrexone is an opioid antagonist with little, if any, opioid agonist activity.

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