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In patients with chronic renal impairmentwhose creatinine clearance ranged from 9-55 ml/minthe disposition of a single dose of 14 C-finasteride was not different from that in healthy volunteersProtein binding also did not differ in patients with renal impairmentA portion of the metabolites which normally is excreted renally was excreted in the faecesIt therefore appears that faecal excretion increases commensurate to the decrease in urinary excretion of metabolitesDosage adjustment in non-dialysed patients with renal impairment is not necessary.

The adverse experience profile in the 1-yearplacebo-controlledPhase III studiesthe 5-year open extensionsand PLESS were similar.

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in healthy volunteers, treatment with proscar did not alter the response of lh and fsh to gonadotropin-releasing hormone indicating that the hypothalamic-pituitary-testicular axis was not affected.

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