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Irreversible retinal damage has been observed in some patients who had received long-term or highdosage 4-aminoquinoline therapy for discoid and systemic lupus erythematosusor rheumatoid arthritis.

Dispense in a tightlight-resistant container as defined in the USP/NFKeep out of the reach of children.

Retinopathy with changes in pigmentation and visual field defects have been reportedIn its early formit appears reversible on discontinuation of hydroxychloroquineIf allowed to developthere may be a risk of progression even after treatment withdrawalCases of maculopathies and macular degeneration have been reported and may be irreversible.

Some people taking this medication over long periods of time or at high doses have developed irreversible damage to the retina of the eyeStop taking hydroxychloroquine and call your doctor at once if you have trouble focusingif you see light streaks or flashes in your visionor if you notice any swelling or color changes in your eyes.

ChildrenThe safety and effectiveness of using this medication have not been established for children when used for the treatment of rheumatoid arthritis or systemic lupus erythematosusChildren are especially sensitive to the side effects of hydroxychloroquine.

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