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Ponstel is generally indicated for the short term treatment of menstrual pain, with the pain ranging from mild to moderate levels.

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When NSAIDs were administered with aspirinthe protein binding of NSAIDs were reducedalthough the clearance of free NSAID was not alteredThe clinical significance of this interaction is not knownSee Table 2 for clinically significant drug interactions of NSAIDs with aspirinsee PRECAUTIONSDrug Interactions

The pharmacological activity of Ponstel in reducing inflammationand possibly fevermay diminish the utility of diagnostic signs in detecting infections.

This medicine may raise the chance of heart and blood vessel side effects like heart attack and strokeIf these happenthey can be deadlyThe risk of these side effects may be greater if you have heart disease or risks for heart diseaseHoweverthe risk may also be raised in people who do not have heart disease or risks for heart diseaseThe risk of these health problems can happen as soon as the first weeks of using Ponstelmefenamic acidand may be greater with higher doses or with long-term useDo not use Ponstelmefenamic acidright before or after bypass heart surgeryThis medicine may raise the chance of very bad and sometimes deadly stomach or bowel side effects like ulcers or bleedingThe risk is greater in older peopleThe risk is also greater in people who have had stomach or bowel ulcers or bleeding beforeThese problems may occur without warning signsTalk with the doctor.

The pharmacological activity of Ponstel in reducing inflammationand possibly fevermay diminish the utility of diagnostic signs in detecting infections.

Do not use any other over-the-counter coldallergyor pain medication without first asking your doctor or pharmacistMany medicines available over the counter contain medicines similar to mefenamic acidsuch as aspirinibuprofenketoprofenor naproxenIf you take certain products together you may accidentally take too much of this type of medicationRead the label of any other medicine you are using to see if it contains aspirinibuprofenketoprofenor naproxen.

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during the first 6 months of pregnancy, ponstel should be used only when prescribed.

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