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KEPPRA is indicated as adjunctive therapy in the treatment of myoclonic seizures in adults and adolescents 12 years of age and older with juvenile myoclonic epilepsy.

KEPPRA tablets should be swallowed wholeKEPPRA tablets should not be chewed or crushed.

The active substance in Keppralevetiracetamis an anti-epileptic medicineEpilepsy is caused by excessive electrical activity in the brainThe exact way in which levetiracetam works is still unclear but it seems to interfere with a protein called synaptic vesicle protein 2Awhich is found in the spaces between nerves and is involved in the release of chemical messengers from nerve cellsThis helps Keppra to stabilise electrical activity in the brain and prevent seizures.

A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetamExperimental data indicate that this binding site is the synaptic vesicle protein SV2Athought to be involved in the regulation of vesicle exocytosisAlthough the molecular significance of levetiracetam binding to SV2A is not understoodlevetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone miceThese findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.

Keppra is not recommended during pregnancy and in women of childbearing potential not using contraception unless clinically necessary.

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